发明名称 |
TRANSNASAL ANTICONVULSIVE COMPOSITIONS AND MODULATED PROCESS |
摘要 |
A novel method of vehicle modulated administration of an anticonvulsive agen t to the mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol (10-80 %) or a glycol (10-80 %), and their combinations with a biological surfactant such a s a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutic al preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.
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申请公布号 |
CA2379365(C) |
申请公布日期 |
2009.11.17 |
申请号 |
CA20002379365 |
申请日期 |
2000.07.24 |
申请人 |
SK CORPORATION |
发明人 |
LI, LIANLI;CHOI, YONG-MOON;KIM, KWON HO |
分类号 |
A61K9/72;A61K31/045;A61K9/00;A61K9/08;A61K31/16;A61K31/165;A61K31/19;A61K31/197;A61K31/4015;A61K31/4166;A61K31/513;A61K31/55;A61K31/5513;A61K45/00;A61K47/06;A61K47/10;A61K47/24;A61K47/28;A61P25/08 |
主分类号 |
A61K9/72 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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