发明名称 |
PIPERIDINE DERIVATIVE AND USE THEREOF |
摘要 |
The present invention provides a novel piperidine derivative and a tachykinin receptor antagonist containing same, as well as a compound represented by the formula (I) wherein R1 is carbamoylmethyl, methylsulfonylethylcarbonyl and the like; R2 is methyl or cyclopropyl; R3 is a hydrogen atom or methyl; R4 is a chlorine atom or trifluoromethyl; R5 is a chlorine atom or trifluoromethyl; and a group represented by the formula (II) is a group represented by the formula (III) wherein R6 is a hydrogen atom, methyl, ethyl or isopropyl; R7 is a hydrogen atom, methyl or a chlorine atom; and R8 is a hydrogen atom, a fluorine atom, a chlorine atom or methyl; or 3-methylthiophen-2-yl, and a salt thereof. |
申请公布号 |
WO2008133344(A3) |
申请公布日期 |
2009.11.12 |
申请号 |
WO2008JP58304 |
申请日期 |
2008.04.23 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED;SHIRAI, JUNYA;MORIMOTO, SHINJI;SUGIYAMA, HIDEYUKI;SAKAUCHI, NOBUKI;YOSHIKAWA, TAKESHI |
发明人 |
SHIRAI, JUNYA;MORIMOTO, SHINJI;SUGIYAMA, HIDEYUKI;SAKAUCHI, NOBUKI;YOSHIKAWA, TAKESHI |
分类号 |
C07D211/60;A61K31/451;A61P1/00;A61P13/02;A61P25/00;C07D401/06;C07D405/06;C07D409/04;C07D409/14;C07D413/06;C07D417/06 |
主分类号 |
C07D211/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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