发明名称 |
In vivo production of small interfering RNAs that mediate gene silencing |
摘要 |
The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaning specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells. |
申请公布号 |
EP1900815(A3) |
申请公布日期 |
2009.11.11 |
申请号 |
EP20070023866 |
申请日期 |
2002.07.12 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
ZAMORE, PHILIP D.;HUTVAGNER, GYORGY;MCLACHLAN, JUANITA;MELLO, CRAIG C.;GRISHOK, ALLA |
分类号 |
A01K67/027;C12N15/11;A01K67/00;A61K31/7088;A61K35/76;A61K48/00;A61P1/16;A61P3/00;A61P7/06;A61P9/00;A61P19/00;A61P25/04;A61P31/12;A61P35/00;A61P37/02;C07H21/02;C12N1/15;C12N1/19;C12N1/21;C12N5/00;C12N5/10;C12N15/09;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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