COATED PARTICULATE CONTAINING PROTON PUMP INHIBITOR

摘要

PROBLEM TO BE SOLVED: To provide a coated particulate for an orally disintegrating tablet containing a benzimidazole proton pump inhibitor, which has good drug release characteristics and can be produced with a good yield, and to provide an orally disintegrating tablet of a benzimidazole proton pump inhibitor having good storage stability. SOLUTION: The coated particulate is obtained by coating a drug layer containing a benzimidazole proton pump inhibitor and a crospovidone fine powder having an average particle size of 3-10 μm on a spherical crystalline cellulose particle and then coating an inert interlayer and an enteric coating layer. The orally disintegrating tablet includes the coated particulate. COPYRIGHT: (C)2010,JPO&INPIT