<p>The invention provides a synthetic route from sarsasapogenin to timosaponin BII a related compounds. A diketone intermediate is provided, which can advantageously used for in situ assembly of complex sugar moieties of the desired glycone end product. The diketone compound is then selectively reduced using a borohydride reducing agent form the desired end product. Certain of the end products and intermediates are novel compounds per se.</p>
申请公布号
WO2009133401(A1)
申请公布日期
2009.11.05
申请号
WO2009GB50445
申请日期
2009.04.29
申请人
PHYTOPHARM PLC;INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES OF THE PLA;CHENG, SHUIHONG;DU, YUGUO;MA, BAIPING;LI, LU;ZHAO, YANG
发明人
CHENG, SHUIHONG;DU, YUGUO;MA, BAIPING;LI, LU;ZHAO, YANG