发明名称 |
METHODS AND COMPOSITIONS FOR ENHANCING DEVELOPMENTAL POTENTIAL OF OOCYTES AND PREIMPLANTATION EMBRYOS |
摘要 |
The invention relates to compositions and methods for enhancing the developmental potential of oocytes or preimplantation embryos by modulating mitochondrial-associated proteins and/or genomic integrity modifier proteins in the oocytes or preimplantation embryos. In one aspect of the invention, the levels of one or more mitochondrial-associated proteins and/or genomic integrity modifier proteins are increased, in particular by introducing the mitochondrial-associated proteins and/or genomic integrity modifier proteins into the oocytes or preimplantation embryos. Oocytes may be fertilized to obtain a zygote with increased levels of one or more mitochondrial-associated proteins and/or genomic integrity modifier proteins. The methods and compositions may be used to improve in vitro fertilization and embryo transfer methods, and nuclear transfer techniques.
|
申请公布号 |
US2009275502(A1) |
申请公布日期 |
2009.11.05 |
申请号 |
US20060917675 |
申请日期 |
2006.06.16 |
申请人 |
MOUNT SINAI HOSPITAL;GENERAL HOSPITAL CORPORATION;BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY |
发明人 |
JURISICOVA ANDREA;CASPER ROBERT;PEREZ GLORIA I. |
分类号 |
A61K38/17;A61B17/435;A61K38/02;C12N5/06;C12N13/00 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|