Prodrug of ICE inhibitor, pharmaceutical composition containing thereof, its use and intermediate

摘要

Prodrug of an ICE inhibitor of formula (I) having good bioavailability. Compound of the general formula (I) is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthma, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemia's and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma.