摘要 |
This invention relates to novel compounds of the Formula I, Ik, Iq1-21, Ir1-21, Is1-21, It1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 ß-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
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申请人 |
VITAE PHARMACEUTICALS, INC.;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
CLAREMON, DAVID A.;ZHUANG, LINGHANG;LEFTHERIS, KATERINA;TICE, COLIN M.;XU, ZHENRONG;YE, YUANJIE;SINGH, SURESH B.;CACATIAN, SALVACION;ZHAO, WEI;HIMMELSBACH, FRANK;ECKHARDT, MATTHIAS |