CONTROLLED RELEASE COMPLEX COMPOSITION COMPRISING HMG-COA REDUCTASE INHIBITORS AND ANGIOTENSIN-II-RECEPTOR BLOCKERS

摘要

PURPOSE: A complex composition of HMG-CoA reductase inhibitor and angiotensin-II-receptor blocker is provided to prevent antagonistic activity and side effect between the drugs and prevent and treat metabolic syndrome. CONSTITUTION: A complex contains a controlled release compartment with HMG-CoA(3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitor as an active ingredient and an immediate release compartment with angiotensin-II-receptor blocker as an active ingredient. The angiotensin-II-receptor blocker is rosartan, valsartan, irbesartan, candesartan, misartan, iprosartan, olmesartan, their isomver or pharmaceutically acceptable salt. The HMG-CoA reductase inhibitor is simvastatin, lovastatin, atorvastatin, pitavastatin, rosuvastatin, fluvastatin, pravastatin, their isomer and pharmaceutically acceptable salt.