发明名称 |
METHODS FOR MANUFACTURING A POLYCLONAL PROTEIN |
摘要 |
The invention relates to methods for manufacturing drug products comprising at least two distinct members of a polyclonal protein, for example a polyclonal antibody, where each distinct member is expressed by a separate population of cells. The methods involve at least an initial step in which the cell populations expressing the distinct members of the polyclonal protein are cultured separately. The individual cell populations, or proteins expressed by the individual cell populations, are combined at a later point of the upstream or downstream processing to result in a single drug product comprising the distinct members of the polyclonal protein.
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申请公布号 |
CA2722348(A1) |
申请公布日期 |
2009.10.29 |
申请号 |
CA20092722348 |
申请日期 |
2009.04.23 |
申请人 |
SYMPHOGEN A/S |
发明人 |
TOLSTRUP, ANNE BONDGAARD;NIELSEN, LARS SOEGAARD;WEILGUNY, DIETMAR;MULLER, CHRISTIAN;WIBERG, FINN C.;GRAVERSEN, JONAS HEILSKOV |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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