发明名称 |
IDENTIFICATION AND CHARACTERIZATION OF HCV REPLICON VARIANTS WITH REDUCED SUSCEPTIBILITY TO A COMBINATION OF POLYMERASE AND PROTEASE INHIBITORS, AND METHODS RELATED THERETO |
摘要 |
The present invention provides methods of decreasing the frequency of emergence, decreasing the level of resistance, and delaying the emergence of a treatment-resistant hepatitis C viral infection, by administering to a subject, either in combination or in series, an inhibitor of the hepatitis C RNA-dependent RNA polymerase NS5B, e.g., a benzofuran, such as 5-cyclopropyl-2-(4-fluorophenyl)- 6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-l-benzofuran- 3-carboxamide (HCV-796), and an inhibitor of the serine protease NS3, e.g., boceprevir. Additionally, the invention relates to methods of monitoring the course of treatment of a hepatitis C viral infection, methods of monitoring and prognosing a hepatitis C viral infection, and methods of identifying an individual with a decreased likelihood of responding to an anti-hepatitis C viral therapy. These methods use the sequence(s) of HCV nonstructural gene(s) to identify the emergence of a treatment-resistant hepatitis C viral infection, particularly a benzofuran (e.g., HCV-796) and NS3 inhibitor (e.g., boceprevir) treatment- resistant hepatitis C viral infection.
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申请公布号 |
WO2009021121(A4) |
申请公布日期 |
2009.10.29 |
申请号 |
WO2008US72492 |
申请日期 |
2008.08.07 |
申请人 |
WYETH;VIROPHARMA INCORPORATED;FLINT, MICHAEL, JAMES;HOWE, ANITA, Y.M.;DEATLY, ANNE MCCLURE |
发明人 |
FLINT, MICHAEL, JAMES;HOWE, ANITA, Y.M.;DEATLY, ANNE MCCLURE |
分类号 |
A61K31/343;A61K38/06;A61P31/14;G01N33/576;G01N33/68 |
主分类号 |
A61K31/343 |
代理机构 |
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