发明名称 |
IMPROVED PRODUCTION METHOD FOR ADEFOVIR DIPIVOXIL |
摘要 |
The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50° C. under the presence of dimethylsulfoxide and triethylamine solvents.
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申请公布号 |
US2011207930(A1) |
申请公布日期 |
2011.08.25 |
申请号 |
US200913119538 |
申请日期 |
2009.09.17 |
申请人 |
CJ CHEILJEDANG CORPORATION |
发明人 |
CHOI KWANG DO;LEE YONG TACK;YOON MYEONG SIK;HONG HYE SUK;CHO IL HWAN;LEE SI BEUM;BANG SEONG CHEOL;OH DA WON;LEE MIN KYOUNG |
分类号 |
C07F9/6561 |
主分类号 |
C07F9/6561 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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