摘要 |
Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction. |
申请人 |
LIFE TECHNOLOGIES CORPORATION;PIPER, DAVID;VOGEL, KURT;SHEKHANI, MOHAMMED SALEH;HESS, STEPHEN;DUFF, STEVE;LIVELLI, THOMAS;ZHONG, ZHONG |
发明人 |
PIPER, DAVID;VOGEL, KURT;SHEKHANI, MOHAMMED SALEH;HESS, STEPHEN;DUFF, STEVE;LIVELLI, THOMAS;ZHONG, ZHONG |