摘要 |
The present invention provides a compound represented by the formula: wherein R<1a>is a hydrogen atom, R<2a> is a C1-6 alkyl group substituted by a group represented by-NR<6a>-CO-(CH2) n-SO2-optionally halogenated C1-4 alkyl wherein n is an integer of 1 to 4, R<6a> is a hydrogen atom or a C 1-4 alkyl group, and -(CH2) n - is optionally substituted by C 1-4 alkyl, R<3a> is a hydrogen atom or a C1-6 alkyl group, R<4a> is a halogen atom or a C 1-6 alkyl group, R<5a> is a halogen atom or a C1-6 alkyl group, and X<a> is a hydrogen atom or a halogen atom, or a salt thereof. The compound of the present invention has a superior tyrosine kinase inhibitory action, is highly safe, and is sufficiently satisfactory as a pharmaceutical product. |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
ISHIKAWA, TOMOYASU;MIWA, KAZUHIRO;SETO, MASAKI;BANNO, HIROSHI;KAWAKITA, YOUICHI |