发明名称 |
Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates |
摘要 |
The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
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申请公布号 |
US7608682(B2) |
申请公布日期 |
2009.10.27 |
申请号 |
US20030693999 |
申请日期 |
2003.10.28 |
申请人 |
MESO SCALE TECHNOLOGIES LLC |
发明人 |
DAVYDOV ILIA;KENTEN JOHN H.;BIEBUYCK HANS;OBEROI PANKAJ |
分类号 |
C07K14/00;A61K39/395;C07K14/47;C07K14/705;C07K16/00;C12N9/64;C12P1/00;C12P13/18;C12Q1/25;C12Q1/37;G01N;G01N33/53;G01N33/573 |
主分类号 |
C07K14/00 |
代理机构 |
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主权项 |
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地址 |
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