发明名称 |
Methods of identifying compounds that inhibit Notch cleavage |
摘要 |
In vitro cell-based methods for identifying compounds that inhibit Notch cleavage and methods for identifying gamma-secretase inhibitors that exhibit reduced induction of goblet cell metaplasia are provided. Also provided are methods of identifying compounds that inhibit cleavage of gamma-secretase substrates other than Notch and homogeneous compositions or cultures of Notch-expressing cells that undergo mucin-2 or mucin-5AC induction in response to a compound known to inhibit Notch cleavage and methods of their generation.
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申请公布号 |
US7608408(B2) |
申请公布日期 |
2009.10.27 |
申请号 |
US20060595721 |
申请日期 |
2006.11.10 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BURTON CATHERINE;ALBRIGHT CHARLES F.;WARDWELL-SWANSON JUDITH A. |
分类号 |
C12Q1/68;C07K14/435;C12N5/09;G01N33/53;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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