| 摘要 |
PROBLEM TO BE SOLVED: To provide a dorzolamide hydrochloride ophthalmic solution with decreased eye irritancy. SOLUTION: In the ophthalmic solution which contains dorzolamide hydrochloride (its chemical name is (-)-(4S, 6S)-4-ethylamino-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride) as an active constituent, the condition for decreasing eye irritancy is discovered. The ophthalmic solution prepared by dissolving dorzolamide hydrochloride in purified water, etc., causes eye irritancy at the time of instillation of drop. Though the pH of the ophthalmic solution, which is exemplified as one cause of eye irritant property, is generally confirmed to be 5.5-5.9 in the acidic region, the condition decreasing the eye irritancy during the instillation of a dorzolamide hydrochloride ophthalmic solution is found to be especially 6.5-8.5 in the neutral region of pH. COPYRIGHT: (C)2010,JPO&INPIT
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