1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11ß -HYDROXYSTEROID DEHYDROGENASE 1

摘要

This invention relates to novel compounds of the Formula (I)1 (I*), (I**), (Ia), (Ib), (Ic), (Id), (Ie)1 (If), (Ig), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 ß-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.