发明名称 |
GENE EXPRESSION INHIBITOR SELECTIVE FOR MATRIX METALLOPROTEINASE-9 GENE |
摘要 |
<p>Disclosed are: an inhibitor of the expression of matrix metalloproteinase-9 gene; a therapeutic agent for a disease associated with matrix metalloproteinase-9; and a carcinostatic agent. Each of the agents comprises a pyrrole-imidazole polyamide having an N-methylpyrrole unit, an N-methylimidazole unit and a ?-aminobutyric acid unit. The pyrrole-imidazole polyamide can be folded at the site of the ?-aminobutyric acid unit to form a U-shaped conformation in a minor groove of a double-stranded domain comprising a part or the whole of a specific nucleotide sequence (SEQ ID NO:2, SEQ ID NO:4) included in a human matrix metalloproteinase-9 gene promoter and a strand complementary to the part or the whole of the specific nucleotide sequence. In the U-shaped conformation, a Py-Im pair, an Im/Py pair and a Py/Py pair in the pyrrole-imidazole polyamide target a C-G base pair, a G-C base pair, and both of an A-T base pair and a T-A base pair in the minor groove, respectively.</p> |
申请公布号 |
WO2009128547(A1) |
申请公布日期 |
2009.10.22 |
申请号 |
WO2009JP57801 |
申请日期 |
2009.04.17 |
申请人 |
NIHON UNIVERSITY;NAGASE, HIROKI;WANG, XIAOFEI |
发明人 |
NAGASE, HIROKI;WANG, XIAOFEI |
分类号 |
A61K31/787;A61P35/00;A61P43/00;C07D403/14 |
主分类号 |
A61K31/787 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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