发明名称 |
SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS |
摘要 |
Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed.
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申请公布号 |
CA2721231(A1) |
申请公布日期 |
2009.10.22 |
申请号 |
CA20092721231 |
申请日期 |
2009.04.14 |
申请人 |
INNOVATIVE TARGETING SOLUTIONS INC. |
发明人 |
GALLO, MICHAEL;KANG, JASPAL SINGH;PIGOTT, CRAIG ROBIN |
分类号 |
C12N15/13;C07K16/18;C12N15/113;C12N15/63 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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