COATING SYSTEMS FOR THE CONTROLLED DELIVERY OF HYDROPHILIC BIOACTIVE AGENTS
摘要
<p>Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.</p>
申请公布号
WO2009128944(A2)
申请公布日期
2009.10.22
申请号
WO2009US02418
申请日期
2009.04.17
申请人
SURMODICS, INC.;CHAPPA, RALPH, A.;HERGENROTHER, ROBERT;WADMAN, SHANNON, A.;WORMUTH, KLAUS, R.
发明人
CHAPPA, RALPH, A.;HERGENROTHER, ROBERT;WADMAN, SHANNON, A.;WORMUTH, KLAUS, R.