发明名称 |
Methods and compositions for treating post-operative pain comprising clonidine |
摘要 |
The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days. |
申请公布号 |
AU2009236157(A1) |
申请公布日期 |
2009.10.22 |
申请号 |
AU20090236157 |
申请日期 |
2009.04.17 |
申请人 |
WARSAW ORTHOPEDIC, INC.;MEDTRONIC, INC. |
发明人 |
CHRISTOPHER M. HOBOT;AMIRA WOHABREBBI;PHILLIP EDWARD MCDONALD;VANJA MARGARETA KING;WILLIAM F. MCKAY;TROY CARTER |
分类号 |
A61K9/00;A61K9/20;A61K31/4162;A61K47/34 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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