| 摘要 |
FIELD: pharmacology. ^ SUBSTANCE: invention concerns compounds of formula I, where R1, R4, R5, R6, R7, R8 is H; R2 is F; A is O; R3 is (C1-C6)-alkyl, and one, several or all hydrogen atoms can be substituted by fluorine; B is (C0-C15)-alkylene; X is CO or link; L is (C1-C6)-alkylene, where in each case one or two -CH2-groups can be substituted by NH, or (C2-C5)-alkenylene; Y is CO, NHCO or link; R9 is hydrogen, (C1-C6)-alkyl, (C1-C6)-alkylene-OH, (C1-C6)-alkylene-NH2 or (C0-C6)-alkylene-CONH2, where one or more CH2-groups of alkyl residue can be substituted by -OH, -OSO3H, -NH-SO3H, adamantly or sugar residue of formula , or R8 and R9 together with their carrier atom N form 5-7-membered saturated cycle Cyc2, where one or more CH2-groups of the cycle can also be substituted by O, NH, NSO3H, N-(C1-C6)-alkyl, and alkyl group can be substituted by -OH group; and pharmaceutically acceptable salts of the claimed compounds. ^ EFFECT: medicine for blood sugar level reduction, containing one or more compounds of formula I; application of compounds of the formula I in obtaining medicine for blood sugar level reduction and for 1st and 2nd type diabetes treatment. ^ 10 cl, 1 tbl, 37 ex |
