发明名称 |
Truncated hepatocyte growth factor variant protein HGF/NK2 |
摘要 |
The present invention relates to a novel truncated form of heptocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.
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申请公布号 |
US7605127(B2) |
申请公布日期 |
2009.10.20 |
申请号 |
US20020283769 |
申请日期 |
2002.10.30 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
CHAN ANDREW M. L.;RUBIN JEFFREY S.;BOTTARO DONALD P.;AARONSON STUART A.;STAHL STEPHEN J.;WINGFIELD PAUL T.;CIOCE VITTORIA |
分类号 |
C07K14/475;A61K38/00;A61K38/18;A61K38/19;C12N15/12;C12N15/18 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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