| 摘要 |
Provided herein are methods of repairing, treating, managing or preventing brain damages. In some embodiments, the methods comprise applying a direct current electric field to direct or modulate the migration of NSPCs towards the region of the brain damage. In certain embodiments, the methods comprise administering an electric field between a cerebral ventricle and the meninx, inclusive, of the brain where the brain damage occurs. In other embodiments, the methods comprise activating a membrane protein of NSPCs by a direct current electric field. In further embodiments, the methods comprise interactions of a membrane protein in NSPC with Rac1, Tiam1, Pak1, and actin cytoskeleton in a protein complex in the presence of an electric field. In still further embodiments, the methods comprise applying an electric field to promote neurogenesis in the subventricular zone or subgranular zone of the brain.
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