发明名称 |
METHODS AND USE OF INDUCING APOPTOSIS IN CANCER CELLS |
摘要 |
The present disclosure relates to a method of inducing apoptosis in a cancer cell by delivery of exogenous Coenzyme QlO or its metabolites thereof in a pharmaceutically acceptable carrier to effectuate cell contact of endogenous Coenzyme QlO or its metabolites thereof in addition to but not limited to mevalonic acid and oleic acid to form an intracellular complex. The present disclosure also provides a method of modulating the p53 pathway and Bcl-2 protein family in a manner that restores the apoptotic potential to a cancer cell by delivery of Coenzyme QlO in a pharmaceutically acceptable carrier. The present disclosure further provides a method to specifically normalize the ratio of pro-apoptotic and anti-apoptotic members of the Bcl-2 gene family in a proportion to re-program a cancer cell to undergo apoptosis. |
申请公布号 |
CA2721071(A1) |
申请公布日期 |
2009.10.15 |
申请号 |
CA20092721071 |
申请日期 |
2009.04.09 |
申请人 |
CYTOTECH LABS, LLC |
发明人 |
NARAIN, NIVEN RAJIN;PERSAUD, INDUSHEKHAR;MCCOOK, JOHN PATRICK |
分类号 |
A61K31/122;A61K9/127;A61P35/00 |
主分类号 |
A61K31/122 |
代理机构 |
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代理人 |
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地址 |
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