发明名称 NEW CRYSTAL FORM OF ATORVASTATIN HEMI-CALCIUM AND METHOD FOR THEIR PREPARATION, AS WELL AS NEW METHOD FOR PREPARING ATORVASTATIN HEMI-CALCIUM FORMS I, VIII AND IX
摘要 <P>PROBLEM TO BE SOLVED: To provide new crystal forms in which a formulation scientist performs the design of a target release profile of atorvastatin hemi-calcium or a pharmaceutical preparation form (dosage form) of a medicine having other desirable characters. Ž<P>SOLUTION: The solid crystalline atorvastatin hemi-calcium or the solvate thereof is characterized in that an atorvastatin hemi-calcium form V is collected from the mixture with water and 1-butanol and has a powder X-ray diffraction pattern which has peaks in 9.3 and 9.5±0.2 degrees 2θ. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
申请公布号 JP2009235083(A) 申请公布日期 2009.10.15
申请号 JP20090137400 申请日期 2009.06.08
申请人 TEVA PHARMACEUTICAL INDUSTRIES LTD 发明人 TESSLER LIMOR;ARONHIME JUDITH;LIFSHITZ-LIRON REVITAL;MAIDAN-HANOCH DALIA;HASSON NIR
分类号 C07D207/34;A61K31/40;A61P3/06;A61P43/00;C07D207/327;C07D405/06 主分类号 C07D207/34
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