A test system for detecting intracellular cyclic nucleotide level and methods and uses thereof

摘要

The present invention relates to a test system for detecting a cyclic nucleotide, the test system comprising (i) a cell comprising an insect cyclic nucleotide-activated ion channel protein or a derivative thereof and (ii) means for detecting the activity of the ion channel protein, methods for detecting a change of an intracellular cyclic nucleotide level, methods of identifying an agent capable of modifying an intracellular cyclic nucleotide level, a kit comprising the cell or means for producing the cell and means for detecting activity and the use of the test system for detecting a change of an intracellular cyclic nucleotide level or for identifying an agent capable of modifying intracellular cyclic nucleotide level.