<p>The present disclosure describes oligomeric compounds having at least one bicyclic nucleoside attached to the 3' or 5' termini by a neutral internucleoside linkage and methods of using the oligomeric compounds. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.</p>
申请公布号
WO2009124238(A1)
申请公布日期
2009.10.08
申请号
WO2009US39438
申请日期
2009.04.03
申请人
ISIS PHARMACEUTICALS, INC.;SETH, PUNIT, P.;SWAYZE, ERIC, E.