| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for industrially producing an optically active fluoroamine compound. <P>SOLUTION: The method for producing the optically active fluoroamine compound comprises dehydration-condensing an optically active hydroxyamine compound with an aldehyde compound to obtain a protected optically active hydroxylamine compound (imine compound, oxazoline compound or their mixture), reacting the protected optically active hydroxylamine compound with sulfuryl fluoride (SO<SB>2</SB>F<SB>2</SB>) in the presence of a 7 to 18C tertiary amine compound to obtain a protected optically active fluoroamine compound, and finally hydrolyzing the protected optically active fluoroamine compound under acidic conditions to produce the optically active fluoroamine compound. The new protected optically active fluoroamine compound is also provided as a useful key intermediate in the production method. <P>COPYRIGHT: (C)2010,JPO&INPIT</p> |
