METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION
摘要
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine mehtyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3- K27) thereby suppressing the transcription of the gene.
申请公布号
WO2009124137(A2)
申请公布日期
2009.10.08
申请号
WO2009US39187
申请日期
2009.04.01
申请人
MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY;ZHOU, MING-MING;MUJTABA, SHIRAZ