LENTIVIRUS-BASED IMMUNOGENIC VECTORS

摘要

The present invention provides for lentiviral vectors for vaccine delivery comprising a 5' long terminal repeat (LTR) and a 3' LTR, an integrated nucleic acid sequence, wherein the integrated nucleic acid sequence is expressed by the 5' LTR; and a nucleic acid sequence encoding functional REV coding sequence and a rev response element (RRE)-containing sequence, wherein the RRE-containing sequence is located upstream of the REV coding sequence, and wherein transcription of said first nucleic acid sequence and said second nucleic acid sequence is driven by said 5' LTR. Also provided for are pharmaceutical compositions, methods of making and using the lentiviral vectors of the present invention.