发明名称 |
INHIBITORS OF DNA IMMUNOSTIMULATORY SEQUENCE ACTIVITY |
摘要 |
The invention consists of oligonucleotides which inhibit the immunostimulato ry activity of ISS-ODN (immunostimulatory sequence oligodeoxynucleotides) as well as methods for their identification and use. The oligonucleotides of the invention are useful in controlling therapeutically intended ISS-ODN adjuvant activity as well as undesired ISS- ODN activity exerted by recombinant expression vectors, such as those used for gene therapy and gene immunization. The oligonucleotides of the invention also have anti-inflammatory activity useful in reducing inflammation in response to infection of a host with ISS- ODN containing microbes, in controlling autoimmune disease and in boosting host Th2 type immune responses to an antigen. The invention also encompasses pharmaceutically useful conjugates of the oligonucleotides of the invention (including conjugate partners such as antigens and antibodies).
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申请公布号 |
CA2293489(C) |
申请公布日期 |
2009.09.29 |
申请号 |
CA19982293489 |
申请日期 |
1998.06.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;DYNAVAX TECHNOLOGIES CORPORATION |
发明人 |
ROMAN, MARK;RAZ, EYAL |
分类号 |
A61K39/39;C12N15/09;A61K31/7052;A61K31/7088;A61K31/7115;A61K38/00;A61K39/385;A61K48/00;A61P37/02;A61P37/06;A61P43/00;C07H21/00;C07K14/00;C07K14/47;C12N15/117;C12Q1/68 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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