METHODS FOR MEASURING PRO-INFLAMMATORY SUBSTANCE LEVELS IN DIALYSIS SOLUTIONS AND DIALYSIS COMPONENTS
摘要
<p>Methods of measuring levels of pro-inflammatory substances in dialysis solutions or specific dialysis components used to manufacture dialysis solutions are provided. In a general embodiment, the method comprises determining an IL-6 response versus a pro-inflammatory substance concentration of a reference standard containing a pro-inflammatory substance and establishing a dose-response curve of the IL-6 responses as a function of different pro-inflammatory substance concentrations of the reference standard. An IL-6 response of a test sample of a dialysis solution is determined. The corresponding pro-inflammatory substance concentration of the dialysis solution is then calculated using the dose-response curve. The IL-6 response of the reference standards and the dialysis solution can be determined using a high sensitivity PBMC IL-6 assay.</p>
申请公布号
WO2009117303(A1)
申请公布日期
2009.09.24
申请号
WO2009US36933
申请日期
2009.03.12
申请人
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;WANG, RUN;HOLMES, CLIFF;SKOUFOS, LINE;HYLA, PAT