发明名称 |
Chemoenzymatic Process for the Stereoselective Preparation of (R)-Gamma-Amino-Beta-Hydroxybutyric Acid [(R)-GABOB) and (R)-Carnitine |
摘要 |
The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparation of racemic 3-hydroxy-4-tosyloxybutanenitrile, its lipase-mediated kinetic resolution and its successful application in the preparation of (R)-GABOB and (R)-carnitine.
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申请公布号 |
US2009233337(A1) |
申请公布日期 |
2009.09.17 |
申请号 |
US20050911643 |
申请日期 |
2005.11.29 |
申请人 |
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH |
发明人 |
KAMAL AHMED;KHANNA GOLLAPALLI BHASKER RAMESH;KRISHNAJI TADIPARTHI;RAMU RONDLA |
分类号 |
C12P13/00 |
主分类号 |
C12P13/00 |
代理机构 |
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代理人 |
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地址 |
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