DILUTE FILTRATION STERILIZATION PROCESS FOR VISCOELASTIC BIOPOLYMERS
摘要
Manufactured hyaluronic acid products are used in numerous surgical applications including viscoelastic supplementation for the treatment of osteoarthritis, however, traditional sterilization techniques result in the breakdown of such high molecular weight viscoelastic biopolymers and are thus unsuitable. Disclosed are processes for obtaining concentrated sterile solutions of high molecular weight biopolymers such as hyaluronic acid. The processes include filter sterilization with a dilute preparation of the biopolymer, and concentration of the dilute filter sterilized biopolymer by ultrafiltration to a desired concentration.
申请公布号
WO2009063291(A8)
申请公布日期
2009.09.17
申请号
WO2008IB03042
申请日期
2008.11.12
申请人
BIO-TECHNOLOGY GENERAL (ISRAEL) LTD.;FUCHS, MENAKHEM;EYAL, DROR;ZELIG, YEHUDA