发明名称 |
NOVEL COMPOSITIONS AND METHODS FOR PROMOTING, INHIBITING, AND DETECTING PROTEIN ENTRY INTO CELLS |
摘要 |
The invention features methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death, by blocking or accelerating, respectively, the translocation of the catalytic domain of toxins or transcription factors through the endosomal membrane into the cytosol of a cell. Also featured are methods for inhibiting cell death that include the administration of polypeptides that include a toxin consensus sequence recognized by one or more components of the cytosolic translocation factor complex. |
申请公布号 |
WO2007126415(A3) |
申请公布日期 |
2009.09.17 |
申请号 |
WO2006US33830 |
申请日期 |
2006.08.30 |
申请人 |
BOSTON MEDICAL CENTER CORPORATION;MURPHY, JOHN, R.;RATTS, RYAN |
发明人 |
MURPHY, JOHN, R.;RATTS, RYAN |
分类号 |
C07K2/00 |
主分类号 |
C07K2/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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