PROCESS FOR MAKING CARBAPENEM COMPOUNDS

摘要

The present invention relates to a process for reducing the levels of organi c solvents to pharmaceutically acceptable levels in thermally unstable crystalline carbapenem solids represented by formula I, or a salt thereof, wherein R1 and R2, are the same or different, and are selected from H, alkyl , aryl, and heteroaryl, comprising washing a carbapenem solid containing organ ic solvent with an organic solvent containing water; and using vacuum and/or inert gas (hydrated or dry) at low temperature to produce a compound of formula I containing pharmaceutically acceptable levels of organic solvents, wherein the water content of the crystalline carbapenem solid, correcting fo r organic solvents, is maintained at about 13% to about 25% during the process .