PROPHYLACTIC OR THERAPEUTIC AGENT FOR OPTIC NERVE DISORDERS COMPRISING 3',5-DI-2-PROPENYL-(1,1'-BIPHENYL)-2,4'-DIOL AS ACTIVE INGREDIENT

摘要

Disclosed is a compound which is useful as a prophylactic or therapeutic agent for optical nerve disorders, an inhibitor of the cell death of retinal ganglion cells or an agent for recovering the expression level of a neurofilament light chain, particularly a compound which can exhibit the above-mentioned physiological activity when administered orally. Specifically disclosed is 3'-5-di-2-propenyl- (1,1'-biphenyl)-2,4'-diol, an ester thereof, or a salt of the compound or the ester. The compound, the ester or the salt can significantly prevent the reduction in the number of cells in a retinal ganglion cell layer in an NMDA-induced retinal disorder model rat when administered orally to the model rat and can recover the reduction in the expression level of a neurofilament light chain in a retina in the model rat when administered intravitreally to the model rat. Therefore, the compound, the ester or the salt is useful as a prophylactic or therapeutic agent for optical nerve disorders, an inhibitor of the cell death of retinal ganglion cells or an agent for recovering the expression level of a neurofilament light chain.