发明名称 |
METHODS FOR MODULATING DE NOVO HEPATIC LIPOGENESIS BY MODULATING XBP-1 ACTIVITY |
摘要 |
The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP- 1 protein, or a protein in a signal transduction pathway involving XBP-I to treat dyslipidemias and steatosis disorders. The present invention also pertains to methods for identifying compounds that modulate the expression, processing, post-translational modification, and/or activity of XBP-I protein or a molecule in a signal transduction pathway involving XBP-1. |
申请公布号 |
WO2009091815(A3) |
申请公布日期 |
2009.09.11 |
申请号 |
WO2009US30976 |
申请日期 |
2009.01.14 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;GLIMCHER, LAURIE, H.;LEE, ANN-HWEE |
发明人 |
GLIMCHER, LAURIE, H.;LEE, ANN-HWEE |
分类号 |
A61K48/00;A61K31/70;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|