| 摘要 |
A process for the preparation of a sucralose which comprises the steps of: reacting a sucrose with a chlorinating reagent in a non-proton type polar solvent to form chlorinated sucrose (4,6,1',6'-tertchloro-4,6,1',6'-tertdeoxylgalactosucrose); reacting the chlorinated sucrose and a carboxylate salt to form sucralose-6-acetate in a dissolvent; and finally de-acylating the sucralose-6-acetate in sodium methoxide/methanol system and then the desired product sucralose is thereby produced. The present invention is generally related to the industrial production of sucralose with the advantages of mild reaction conditions, high yield rate, and brief operation.
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