发明名称 Biotin intermediate and process for preparing the same
摘要 <p>Disclosed is a process for preparing a compound represented by the formula (IX): R-X-Y (IX) wherein R represents an alkyl group which may have a substituent(s), a bicyclo group which may have a substituent(s), an alkenyl group which may have a substituent(s), a heterocyclic group which contains 1 to 4 atoms selected from nitrogen atom, oxygen atom and sulfur atom as a hetero atom(s) and may have a substituent(s) or an aryl group which may have a substituent(s), X represents zinc or magnesium, Y represents iodine, bromine, chlorine, which comprises reacting a compound represented by the formula (VIII): R-I (VIII) wherein R has the same meaning as defined above, with zinc or magnesium which has been treated by chlorine, bromine, hydrogen chloride or hydrogen bromide; or with zinc or magnesium in the presence of a base represented by the formula (X): M-Y (X) wherein M represents a metal atom, and Y has the same meaning as defined above.</p>
申请公布号 EP2098528(A2) 申请公布日期 2009.09.09
申请号 EP20090159038 申请日期 2002.12.04
申请人 MITSUBISHI TANABE PHARMA CORPORATION 发明人 SEKI, MASAHIKO;SHIMIZU, TOSHIAKI;YOSHIDA, SHIN-ICHI;HATSUDA, MASANORI
分类号 C07D233/32;C07D277/14;C07D495/04;C07F3/02;C07F3/06 主分类号 C07D233/32
代理机构 代理人
主权项
地址