The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents The present invention also pertains to the identification of regions of the discodermolide molecule which are responsib le for certain aspects of the bioactivity of discodermolide compounds.
申请公布号
CA2401160(C)
申请公布日期
2009.09.08
申请号
CA20012401160
申请日期
2001.02.28
申请人
HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC.
发明人
GUNASEKERA, SARATH P.;PAUL, GOPAL K.;POMPONI, SHIRLEY A.;ISBRUCKER, RICHARD A.;LONGLEY, ROSS E.;WRIGHT, AMY E.