发明名称 Synthesis of [1-13C]pyruvic acid], [2-13C]pyruvic acid], [3-13C]pyruvic acid] and combinations thereof
摘要 The present invention is directed to labeled compounds, of the formulae wherein C* is each independently selected from the group consisting of 13C and 12C with the proviso that at least one C* is 13C, each hydrogen of the methylene group can independently be either hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is from the group of sulfide, sulfinyl, and sulfone, Z is an aryl group from the group of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently from the group of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group from the group of NH2, NHR and NRR' where R and R' are each independently from the group of a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms.
申请公布号 US7582801(B2) 申请公布日期 2009.09.01
申请号 US20050052589 申请日期 2005.02.07
申请人 LOS ALAMOS NATIONAL SECURITY, LLC 发明人 MARTINEZ RODOLFO A.;UNKEFER CLIFFORD J.;ALVAREZ MARC A.
分类号 C07C49/04 主分类号 C07C49/04
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