A2B adenosine receptor antagonists

摘要

Disclosed is a process for preparing A2B adenosine receptor antagonists of Formula I, wherein R1 is N-propyl, R2 is ethyl, X is pyrazol-4-yl, Y is methylene and Z is 3-trifluoromethylphenyl, comprising cyclising a compound of formula (3), which has been prepared from either a compound of formula (16) or a compound of formula (13). The compounds of Formula I are useful for treating asthma and diarrhea. Also disclosed are intermediates useful in the claimed process.