发明名称 |
PROCESS FOR THE PREPARATION OF ARIPIPRAZOLE, NOVEL INTERMEDIATES AND PROCESS FOR THEIR PREPARATION |
摘要 |
The invention disclosed in this application relates to an improved process for the preparation of aripiprazole (1) which comprises (i) Reacting 6-hydroxy-l-indanone (11) with 1,4-dihalobutane (12) in the presence of a base and a solvent at a temperature in the range of 90 to 110°C to form the novel intermediate 6-(4-halo butoxy)-indan-l-one (3), (ii) reacting the novel intermediate with 1-(2,3-clichlorophenyl)-piperazine (9) to get another novel intermediate 6-[4-[4-(2,3-dichlorophenyl)-l-piperazinyl] butoxy]-indan-l-one (2) and (iii) Reacting the resulting novel compound with sodium azide. The invention also relates to the novel intermediates of the formulae (2) & (3) and processes for their preparation. |
申请公布号 |
EA012180(B1) |
申请公布日期 |
2009.08.28 |
申请号 |
EA20070000816 |
申请日期 |
2004.10.08 |
申请人 |
SUVEN LIFE SCIENCES LIMITED |
发明人 |
CHINNAPILLAI RAJENDIRAN;ARAVA VEERA, REDDY;ATHUKURU VENKATA SUBBA, RAO;JASTI VENKATESWARLU |
分类号 |
C07D215/22;C07C49/67;C07D295/088 |
主分类号 |
C07D215/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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