Controlled release formulations of opioid and nonopioid analgesics such as hydrocodone and acetaminophen

摘要

Disclosed is a sustained release dosage form for twice daily oral dosing to a human patient, comprising a) a semipermeable wall defining a cavity and having an exit orifice formed or formable therein; b) a push displacement layer contained within the cavity and located distal to the exit orifice; c) a sustained release drug layer contained within the cavity, wherein said sustained release drug layer contains a therapeutically effective amount of an opioid analgesic such as hydrocodone and a therapeutically effective amount of non-opioid analgesic such as paracetamol, wherein said amount of non-opioid analgesic is between 20 and 100 times said amount of opioid analgesic by weight, wherein said sustained release drug layer is released from the dosage form as an erodible solid to provide sustained release of each of said opioid analgesic and said non-opioid analgesic at rates proportional to each other in said dosage form such that the release rate of said opioid analgesic does not deviate more than about 20% of the release rate of said non-opioid analgesic at the same point in time.