| 摘要 |
The present invention provides TCRs having an affinity (KD) of less than or equal to 1 muM, and/or an off-rate (koff) of 1x10-3S-1 or slower, for the SLYNTVATL-HLA-A*0201 complex provided that when the said TCR is presented by cell and comprises SEQ ID NOS:1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex.
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