发明名称 |
ATTENUATED REOVIRUS |
摘要 |
Compositions and methods are provided that relate to an attenuated reovirus exhibiting oncolytic activity toward cancer cells while displaying reduced lytic activity toward non-malignant cells. Exemplified is an attenuated human reovirus derived from persistently infected fibrosarcoma cells that lacks wild-type reovirus S1 and S4 genes and consequently lacks a detectable reoviral outer capsid sigma1 protein and expresses a mutated reoviral outer capsid sigma3 protein.
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申请公布号 |
US2009214479(A1) |
申请公布日期 |
2009.08.27 |
申请号 |
US20060997537 |
申请日期 |
2006.07.31 |
申请人 |
UNIVERSITY TECHNOLOGIES INTERNATIONAL, INC.;UTI LIMITED PARTNERSHIP |
发明人 |
KIM MANBOK;JOHNSTON RANDAL N. |
分类号 |
A61K45/00;A61P35/00;C12N7/04 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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