发明名称 |
RNA DELIVERY VEHICLES |
摘要 |
The present invention relates to double stranded nucleic acid (dsNA) delivery vehicles comprising a dsNA, and a clostridial endosomal translocation domain. Said delivery vehicle may further comprise a non-cytotoxic protease and/ or a Targeting Moiety (TM). The present invention also provides a method for delivering an RNA guide strand into a target cell, and to the use of a dsNA delivery vehicle for down-regulating mRNAactivity in a target cell. In one embodiment, the RNA guide strand binds to a SNARE mRNA target sequence, which leads to the suppression of SNARE protein expression in the target cell. |
申请公布号 |
WO2009083738(A3) |
申请公布日期 |
2009.08.27 |
申请号 |
WO2008GB51232 |
申请日期 |
2008.12.31 |
申请人 |
SYNTAXIN LIMITED;CHADDOCK, JOHN;BEARD, MATTHEW |
发明人 |
CHADDOCK, JOHN;BEARD, MATTHEW |
分类号 |
A61K47/48;A61P1/06;A61P11/00;A61P25/14;A61P35/00;A61P37/08 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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